Publications

2025

1. Xiaoshu Pan, Peixin Huang, Samantha Ali, Bryan Renslo, Tarun E Hutchinson, Nina Erwin, Zachary F Greenberg, Zuo Ding, Yanjun Li, Athanasia Warnecke, Natalia E Fernandez, Hinrich Staecker, and Mei He*, Extracellular vesicle–mediated gene editing for the treatment of nonsyndromic progressive hearing loss in adult mice, 2025, Science Translational Medicine, 17,eadn3993(2025).
2. Zachary F Greenberg, Samantha Ali, Thomas D. Schmittgen, Song Han, Steven J. Hughes, Kiley S. Graim, and Mei He*, Nanomaterial isolated extracellular vesicles enable high precision identification of tumor biomarkers for pancreatic cancer liquid biopsy, 2025, Journal of Nanobiotechnology, 23(1), 467.
3. Tereas Tran, Wenshu Zheng, Tony Hu, David A. Issadore, Hyungsoon Im, Yoon-Kyoung Cho, Yuanqing Zhang, Dingbin Liu, Yang Liu, Fei Liu, David Tai Wai Wong, Jiashu Sun, Kun Qian, Mei He, Meihua Wan, Yong Zeng, Ke Cheng, Tony Jun Huang, Daniel Chiu, Luke P. Lee, Lei Zheng, Andrew Godwin, Raghu Kalluri, Steven A Soper, Extracellular Vesicles for Clinical Diagnostics: From Bulk Measurements to Single-Vesicle Analysis, 2025, ACS Nano, 2025, 19, 31, 28021–28109.
4. Zachary Greenberg, Regina Oshins, Karina Serban, Sina F. Bazargani, Timothy Garrett, Mei He*, Nazli Khodayari*, Neutrophil-derived extracellular vesicles in the plasma of alpha-1 antitrypsin deficient individuals reveal pro-inflammatory metabolic and transcriptomic signatures, 2025, Extracellular Vesicles, 6, 100093.
5. Kuntala Dey, Nina Erwin, Nicolas Molina, Hui Chen, Mei He, Guangrong Zheng, Nano-TPD: Using nanoparticle-based systems to improve the delivery and therapeutic effect of targeted protein degraders, 2025, Medicinal Chemistry Research, https://doi.org/10.1007/s00044-025-03454-w
6. Andrew A. Brock, Senthilkumar Duraivel, Jinmai Jiang, Jonathan Fischer, Zachary F. Greenberg, Mei He, Thomas E. Angelini*, Thomas D. Schmittgen*, RNA Sequencing at Single Vesicle Resolution via 3D Printed Embedded Droplet Arrays, 2025, ACS Applied Materials & Interfaces, 17, 38, 53110–53121.
7. Regina Oshins, Zhiguang Huo, Brittney Poole, Virginia Clark, Huiping Zhou, Jesse West, Matthew Wheeler, Mahya Aghaee, Mei He, Mark Brantly, Nazli Khodayari, Plasma extracellular vesicle-derived microRNA associated with human alpha-1 antitrypsin deficiency-mediated liver disease, Journal of Clinical and Translational Hepatology, 2025, 28;13(2):118-129. BioRxiv doi: https://doi.org/10.1101/2023.08.31.555751
8. Brian Diaz, Pei Zhuang, Xiaoshu Pan, George Doctsc, Mei He*, Engineering Stimuli-Responsive Extracellular Vesicles (EVs) for Enhanced Anti-cancer Therapeutics, 2025, Current Opinion in Biomedical Engineering, 100634.
9. Samantha Ali#, Maddalena Parafati#, Zachary Greenberg, Nina Erwin, Zon Thwin, Mei He*, Siobhan Malany*, Extracellular Vesicle Transcriptomic Analysis to Investigate Mucle Adaption in Microgravity,2025, iScience, Under Revision.
10. Zachary Greenberg, Tarun Hutchinson, Johnathan Kahn, Kiley S. Graim, Padraic O’Malley^*, Mei He^*, Urinary extracellular vesicles for high-precision bladder cancer subtyping and prognosis, 2025, Journal of Extracellular Biology, Under Review.
11. Samantha Ali, Fabiana Mastantuono, Andrea Orozco-Torres, Niloy Barua, Xin Zhou, Lizi Wu, and Mei He*, High-throughput Generation of Collagen Microbeads for Extracellular Vesicle Production and Therapeutic Delivery, 2025, Advanced Material Technologies, Accepted.
12. Nina Erwin, Umasankar De, Yufeng Xiao, Lei Wang, Chandra Maharjan, Xiaoshu Pan, Nikee Awasthee, Guangrong Zheng, Daiqing Liao, Weizhou Zhang, and Mei He*, Proteolysis targeting chimera loaded extracellular vesicles for developing triple negative breast cancer treatment, 2025, Journal of Extracellular Vesicles, In press.
13. Corey Perkins, Jinmai Jiang, Kalyanee Shirlekar, Zachary Greenberg, Md Talha Siddique, Jason Brant, Kiley Graim, Mei He, Sarah Kim, Diana Wilkie, Bo Han, Jamel Ali, Alexander Krasnitz, Pascal Belleau, Astrid Deschênes, and Mazhar Kanak, Thomas Schmittgen, Transcriptomic analyses of normal human pancreas reveal the presence of cancer subtypes that correlate with acinar ductal metaplasia and donor ancestry, 2025, Cancer Research Communications, In press.
14. Kariman Shama, Zachary Greenberg, Evangeline Meyler, Emily Brown, Mei He, Brittany Taylor, Extracellular Matrix Microarchitecture Modulates Cellular Behavior and Extracellular Vesicle Phenotypes in Biomimetic Tendon Models, 2025, Bioengineering & Translational Medicine, In press.
    
    

2024

1. X. Pan, Y. Li, P. Huang, H. Staecker, M. He*, Extracellular Vesicles for Developing Targeted Hearing Loss Therapy, Journal of Controlled Release, 2024, 366, 460-478. Featured as the Cover Art.
2. Welsh JA, Goberdhan DCI, O’Driscoll L, et al. Minimal information for studies of extracellular vesicles (MISEV2023): from basic to advanced approaches, Journal of Extracellular Vesicles, 2024, 13(2):e12404. 
3. Z. Ding, Z. Greenberg, M. Serafim, S. Ali, J. Jamieson, D. O. Traktuev, K. March, M. He*, Understanding Molecular Characteristics of Extracellular Vesicles Derived from Different Types of Mesenchymal Stem Cells for Therapeutic Translation, Extracellular Vesicles, 2024, 3  100034.
4. Kariman A. Shama, Zachary Franklin Greenberg, Chadine Tammame, Mei He, Brittany L. Taylor, Diseased Tendon Models Demonstrate Influence of Extracellular Matrix Alterations on Extracellular Vesicle Profile, Bioengineering, 2024, 11, 1019. https://doi.org/10.3390/bioengineering11101019

2023

1. Z. Greenberg, K. Graim, M. He*, Towards artificial intelligence-enabled extracellular vesicle precision drug delivery, Advanced Drug Delivery Reviews, 2023, 199, 114974.
2. Yufeng Xiao, Seth Hale, Nikee Awasthee, Chengcheng Meng, Xuan Zhang, Yi Liu, Haocheng Ding, Zhiguang Huo, Dongwen Lv, Weizhou Zhang, Mei He, Guangrong Zheng, Daiqing Liao, HDAC3 and HDAC8 PROTAC dual degrader reveals roles of histone acetylation in gene regulation, Cell Chemical Biology, 2023, 30, 1–15.
3. Shaobo Ruan, Wellington J. Jr Rody, Shivani S. Patel, Lina I. Hammadi, Macey L. Martin, Lorraine P. de Faria, George Daaboul, Leif S. Anderson, Mei He*, L. Shannon Holliday, Receptor activator of nuclear factor-kappa B is enriched in CD9-positive extracellular vesicles released by osteoclasts, Extracellular Vesicles and Circulating Nucleic Acids, 2023;4:518-529.

2022

1. Nina Erwin, Maria Fernanda Serafim, M. He*, Enhancing the Cellular Production of Extracellular Vesicles for Developing Therapeutic Applications, Pharmaceutical Research, 2022, https://doi.org/10.1007/s11095-022-03420-w.
2. Jillian Walker, Padraic O’Malley, M. He*, Applications of Exosomes in Diagnosing Muscle Invasive Bladder Cancer, Pharmaceutics, 2022, 14, 2027.
3. S. Ruan, Y. Huang, M. He, H. Gao, Advanced Biomaterials for Cell-Specific Modulation and Restore of Cancer Immunotherapy, Advanced Science, 2022, 2200027.
4. S. Ruan, N. Erwin, M. He*, Light-induced high-efficient cellular production of immune functional extracellular vesicles, Journal of Extracellular Vesicles, 2022, 11, e12194.
5. N. He, S. Thippabhotla, C. Zhong, Z. Greenberg, L. Xu, Z. Pessetto, A. K. Godwin, Y. Zeng, M. He*, Nano pom-poms prepared exosomes enable highly specific cancer biomarker detection, Nature Communications Biology, 2022, 5, 660.

2021

1. P. Zhuang, Y. Chiang, M. S. Fernanda, M. He*, Using Spheroids as building blocks towards 3D bioprinting of tumor microenvironment, International Journal of Bioprinting, 2021, 7(4):444.
2. S. Hong, S. Ruan, Z. Greenberg, M. He, Jodi McGil, Development of Surface Engineered Antigenic Exosomes as Vaccines for Respiratory Syncytial Virus, Scientific Reports, 2021, 11,21358.

3. B. J. Stottlemire, J. W. Whitlow, A. R. Chakravarti, C. J. Berkland, M. He*, Remote-controlled 3D Porous Ferromagnetic Interface towards High- throughput Dynamic 3D Cell Culture, ACS Biomaterials Science & Engineering, 2021, 7, 9, 4535–4544.

Featured as the Cover Art

4. P. Zhuang, S Phung, A Warnecke, A Arambula, MS Peter, M He*, H Staecker*, Isolation of sensory hair cell specific exosomes in human perilymph, Neuroscience Letters, 2021, 136282.

5. P. Zhuang, Z. Greenberg, M. He*, Biologically Enhanced Starch Bio-ink for Promoting 3D Cell Growth, Advanced Materials Technologies, 2021, 2100551.

6. S. Ruan, Z. Greenberg, X. Pan, P. Zhuang, N. Erwin, M. He*, Extracellular Vesicles as an Advanced Delivery Biomaterial for Precision Cancer Immunotherapy, Advanced Healthcare Materials, 2021, 2100650.

7. B. J. Stottlemire, J. D. Miller, J. Whitlow, P. Dhar, M. He, C. J. Berkland, Remote Sensing and Remote Actuation via Silicone–Magnetic Nanorod Composites, Advanced Materials Technologies, 2021, 6 (6), 2001099

8. R. Elliott, M. He*, Unlocking the Power of Exosomes for Crossing Biological Barriers in Drug Delivery, Pharmaceutics, 2021, 13, 122.

2020

1. S. Hong, S. Ruan, P. Gamero Kubota, M. He, J.L. McGill, Immunogenic potency of engineered exosomes for prevention of respiratory syncytial virus, The Journal of Immunology, 2020, 204 (1 Supplement), 245.22-245.22.

2019

1. Q. Zhu, M. Hamilton, B. Vasquez, M. He*, 3D-printing Enabled Micro-assembly of Microfluidic Electroporation System for 3D Tissue Engineering, Lab on a Chip, 2019, 19, 2362-2372 .

Featured as the Emerging Investigator

2. S. Thippabhotla, C. Zhong, M. He*, 3D cell culture stimulates the secretion of in vivo like extracellular vesicles, Scientific Reports, 2019, 9, 13012 .

Featured as the Top 100 Read Articles of 2019

3. P. Zhang, X. Zhou, M. He, Y. Shang, A. L. Tetlow, A. K. Godwin, Y. Zeng, Ultrasensitive detection of circulating exosomes with a 3D-nanopatterned microfluidic chip , Nature Biomedical Engineering, 2019, 3, 438-451.

Featured in the Editorial: Clever Chip Designs for Diagnostics, Nature Biomedical Engineering, 2019, 3, 417.

Featured in the News: Enhanced Detection of Tumor-secreted vesicles, Nature Biomedical Engineering, 2019, 4, 421.

4. Z. Zhao, J. McGill, P. Gamero Kubota, M. He*, Microfluidic On-demand Engineering of Exosomes towards Cancer Immunotherapy,  Lab on a Chip, 2019, 19, 1877 – 1886

2018

1. Q. Zhu, M. Heon, Z. Zhao, M. He*, Microfluidic Engineering of Exosomes: Editing Cellular Messages for Precision Therapeutics. Lab on a Chip, 2018, 18, 1690-1703.

Featured as the Cover Story

2016

1. K. Plevniak, M. Campbell, T. Myers, A. Hodges, M. He*, 3D Printed Auto-mixing Chip Enables Rapid Smartphone Diagnosis of Anemia. Biomicrofluidics, 2016, 10, 054113.

ScienceDaily News, 3D Printing Industry News

2. Z. Zhao, Y. Yang, Y. Zeng, M. He*, A Microfluidic ExoSearch Chip for Multiplexed Exosome Detection Towards Blood-based Ovarian Cancer Diagnosis. Lab on a Chip, 2016, 16, 489-496.

Back Cover Story, RSC Most Download Articles of 2016

3. M. He, Y. Zeng, Microfluidic Exosome Analysis towards Liquid Biopsy for Cancer. Journal of Laboratory Automation, 2016, 21, 599-608.

SLAS Reader Choice Award 2018

4. P. Zhang, M. He, Y. Zeng, Ultrasensitive microfluidic analysis of circulating exosomes using a nanostructured graphene oxide/polydopamine coating. Lab on a Chip, 2016, 16, 3033-3042.

Featured as the Emerging Investigator

5. K. Plevniak, M. He*, Microfluidic Technology: the Next–generation Drug Discovery Tool. Drug Target Review, 2015, 2(3), 18-20.

Work prior to being the PI

M. He, J. Crow, M. Roth, Y. Zeng, A. K. Godwin, Integrated immunoisolation and protein analysis of circulating exosomes using microfluidic technology. Lab on a Chip, 2014, 14, 3773-3780. Royal Chemistry Society Lab On a Chip 2014 Most Accessed Article, KU Cancer Center News and Research Highlights, Labmedica Daily Clinical Lab News

D. Kim, K. Karns, S. Tia, M. He, A. E. Herr, Electrostatic protein immobilization using charged polyacrylamide gels and cationic detergent microfluidic Western blotting. Analytical Chemistry, 2012, 84, 2533-2540.

M. He, Y. Zeng, A. Jemere, D. J. Harrison, Tunable thick polymer coatings for on-chip electrophoretic protein and peptide separation. Journal of Chromatography A, 2012, 1241, 112-116.

M. He, J. Novak, B. A. Julian, A. E. Herr, Membrane-assisted online renaturation for automated microfluidic lectin blotting. Journal of the American Chemical Society, 2011, 133, 19610-19613.

S. Q. Tia, M. He, D. Kim, A. E. Herr, Multi-analyte on-chip native western blotting. Analytical Chemistry, 2011, 83, 3581–3588.

M. He, A. E. Herr, Automated microfluidic protein immunoblotting. Nature Protocols, 2010, 5, 1844-1856.

M. He, J. Bao, Y. Zeng, D. J. Harrison, Parameters governing reproducibility of flow properties of porous monoliths photopatterned within microfluidic channels. Electrophoresis, 2010, 31, 2422-2428.

M. He, A. E. Herr, Polyacrylamide gel photopatterning enables automated protein immunoblotting in a two-dimensional microdevice. Journal of the American Chemical Society, 2010, 132, 2512-2513. JACS front web page highlights

M. He, A. E. Herr, Microfluidic polyacrylamide gel electrophoresis with in-situ immunoblotting for native protein analysis. Analytical Chemistry, 2009, 81, 8177-8184.

M. He, Y. Zeng, X. Sun, D. J. Harrison, Confinement effects on the morphology of photopatterned porous polymer monoliths for capillary and microchip electrophoresis of proteins. Electrophoresis, 2008, 29, 2980-2986.

Y. Zeng, M. He, D. J. Harrison, Microfluidic Self-Patterning of Large-Scale Crystalline Nanoarrays for High-Throughput Continuous DNA Fractionation. Angewandte Chemie International Edition, 2008, 47, 6388-6391.